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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HIRA All Species: 26.06
Human Site: T508 Identified Species: 35.83
UniProt: P54198 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P54198 NP_003316.3 1017 111835 T508 L L P L D S S T P N S F G A S
Chimpanzee Pan troglodytes XP_001165585 1017 111787 T508 L L P L D S S T P N S F G A S
Rhesus Macaque Macaca mulatta XP_001112873 1138 124408 T629 L L P L D S S T P N S F G A S
Dog Lupus familis XP_543550 1017 111618 T508 L L P L D S S T P N S F G A S
Cat Felis silvestris
Mouse Mus musculus Q61666 1015 111748 T508 L L P L D S S T P S F G A S K
Rat Rattus norvegicus NP_001129232 1015 111665 T508 L L P L D S S T P S F G A S K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P79987 1019 112055 L508 N N Q Q L M S L D S N A A N S
Frog Xenopus laevis Q8QFR2 1013 112021 T508 L I S L D S N T T S S S G A L
Zebra Danio Brachydanio rerio XP_696478 1010 111223 L508 D S N T A N S L G L R P S H D
Tiger Blowfish Takifugu rubipres O42611 1025 111838 G508 L S S D S S P G Q A P P L G L
Fruit Fly Dros. melanogaster O17468 1047 113397 D505 K I D L G R L D S R L K T Q P
Honey Bee Apis mellifera XP_001122939 838 91355 E354 L I E F T Q Q E L G Q P L D P
Nematode Worm Caenorhab. elegans Q09589 935 103412 N451 S K E N E S K N S E K T M M E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays Q32SG6 964 105548 Q480 Q L S S P V K Q R E Y R R P D
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LXN4 1051 115544 A508 H N F L P A S A A A P A K G D
Baker's Yeast Sacchar. cerevisiae P32479 840 93871 N356 L V A F D I A N K S I T D M S
Red Bread Mold Neurospora crassa Q7RZI0 1035 112420 S506 V A P L L V S S S G T G L S S
Conservation
Percent
Protein Identity: 100 99.9 88.4 96.5 N.A. 95.7 95.5 N.A. N.A. 86 78 69.8 67.7 31.1 40 26.5 N.A.
Protein Similarity: 100 99.9 88.9 98 N.A. 97.5 97.7 N.A. N.A. 93.1 88.5 83.2 81.3 48 55.1 46.1 N.A.
P-Site Identity: 100 100 100 100 N.A. 60 60 N.A. N.A. 13.3 53.3 6.6 13.3 6.6 6.6 6.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 73.3 73.3 N.A. N.A. 26.6 73.3 13.3 13.3 13.3 13.3 13.3 N.A.
Percent
Protein Identity: N.A. 25.6 N.A. 25 22.4 25.9
Protein Similarity: N.A. 43.7 N.A. 43.3 41.2 45.8
P-Site Identity: N.A. 6.6 N.A. 13.3 20 26.6
P-Site Similarity: N.A. 6.6 N.A. 20 40 53.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 6 6 0 6 6 6 6 6 12 0 12 18 30 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 6 0 6 6 48 0 0 6 6 0 0 0 6 6 18 % D
% Glu: 0 0 12 0 6 0 0 6 0 12 0 0 0 0 6 % E
% Phe: 0 0 6 12 0 0 0 0 0 0 12 24 0 0 0 % F
% Gly: 0 0 0 0 6 0 0 6 6 12 0 18 30 12 0 % G
% His: 6 0 0 0 0 0 0 0 0 0 0 0 0 6 0 % H
% Ile: 0 18 0 0 0 6 0 0 0 0 6 0 0 0 0 % I
% Lys: 6 6 0 0 0 0 12 0 6 0 6 6 6 0 12 % K
% Leu: 59 42 0 59 12 0 6 12 6 6 6 0 18 0 12 % L
% Met: 0 0 0 0 0 6 0 0 0 0 0 0 6 12 0 % M
% Asn: 6 12 6 6 0 6 6 12 0 24 6 0 0 6 0 % N
% Pro: 0 0 42 0 12 0 6 0 36 0 12 18 0 6 12 % P
% Gln: 6 0 6 6 0 6 6 6 6 0 6 0 0 6 0 % Q
% Arg: 0 0 0 0 0 6 0 0 6 6 6 6 6 0 0 % R
% Ser: 6 12 18 6 6 53 59 6 18 30 30 6 6 18 42 % S
% Thr: 0 0 0 6 6 0 0 42 6 0 6 12 6 0 0 % T
% Val: 6 6 0 0 0 12 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 6 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _